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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in grown-ups with a body mass index (BMI) in excess of 27, given that they also have problems with weight-related health issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so that as an aid to stop smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight reduction for people who are obese or are overweight and possess at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had a normal weight loss of 4.1% instead of participants who were given placebos) after a 12- month period, while a separate study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at one year.

    Using two separate drugs to shed pounds can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you should err to the side of caution and allow the FDA do its job and demand some study be done so your public knows the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies come in business to generate money and that they would say anything to keep people on their own medications.

    Researchers found out that participants investing in this drug to get a year, lost excess weight within 4 weeks and have kept the extra weight off through the 56 weeks of the study. Contrave is a combination of the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which are made up of more than one active ingredient, which may make them far better and safer.

    Combo-pilling will be the newest fad or better yet the newest in the future under scrutiny and so it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular will be the fact that at the time of right now there aren't long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA.

    Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise blood pressure and pulse rate, and mustn't be used in those with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure, and also by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients on the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

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