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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) of more than 27, provided they also have problems with weight-related medical issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder in addition to being an aid to stop smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and also have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical activity. Results from a medical trial that enrolled patients without diabetes demonstrated that patients had a typical weight loss of four years old.1% as opposed to participants who were given placebos) after a 12- month period, while a separate study involving patients with diabetes type 2 had a typical weight loss of 2% over treatment with placebo at 12 months.
Using two separate drugs to shed weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people who go through it one should err assisting caution and allow FDA do its job and demand some research be done so your public recognizes the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say everything to keep people on the medications.
Researchers found that participants taking this drug to get a year, lost excess weight within four weeks and have kept the weight off through the entire 56 weeks with the study. Contrave can be a combination from the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of multiple active ingredient, that might make them more potent and safer.
Combo-pilling will be the newest fad or even better the newest in the future under scrutiny and so it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular may be the fact that since right now there are not any long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be authorized by the FDA.
Seizures are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug also can raise blood pressure levels and heart rate, and really should not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.
The FDA also warned that Contrave can raise blood pressure and heartbeat and must not be used in patients with uncontrolled high blood pressure, in addition to by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients on the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.
'The intent of the bill would be to give police officers and district attorneys a power tool to address illicit drug use among expectant women through treatment programs," Tennessee governor Bill Haslam said.