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Evidence is increasing that all addiction without exception is related to problems with the brain's reward center, specially the mesolimbic system. This section of the problem regulates reward responses in establishing food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you need to err assisting caution and allow the FDA do its job and demand some research be done so that the public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on his or her medications.
Researchers found that participants investing in this drug for the year, dropped a few pounds within four weeks and have kept the load off during the entire 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which can be made up of multiple active ingredient, which may make them more potent and safer.
Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and therefore it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular is the fact that at the time of right now there are no long term prescription weightloss pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be authorized by the FDA.
Seizures can be a side effect with Contrave and must not be taken in those with seizure disorders. The drug could also raise blood pressure levels and heart rate, and must not be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.
The FDA also warned that Contrave can raise hypertension and heartrate and must stop used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients having a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients towards the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.
Most of the combinations which can be used to enhance weight loss involve an amphetamine and an antidepressant. Phentermine and Prozac can be a popular combination that were around for quite a while, although it has been around nobody wants to truly combine both and try to get FDA approval to promote it as a weight-loss pill. Right there should raise some warning flag if the greedy pharmaceutical companies should not be involved in combining medications and selling them something have to be wrong while using combination. In fairness there's one fat loss combination pill that is in front of the FDA now Contrave?which couples naltrexone, accustomed to treat alcohol and abusing drugs, with the antidepressant bupropion (Wellbutrin, Zyban) it has been given the just do it to move forward by an FDA advisory committee, but as of yet will not be approved.