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Evidence is increasing that all addiction without exception is related to difficulty with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in establishing food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both when they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to lose weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the people who go through it you need to err to the side of caution and allow FDA do its job and demand some study be done in order that the public recognizes the side effects and perils associated with the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say almost anything to keep people on their medications.
Researchers found that participants taking this drug for a year, lost excess weight within one month and have kept the extra weight off through the 56 weeks with the study. Contrave is often a combination with the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of several active ingredient, which might make them more efficient and safer.
Combo-pilling is the newest fad or also the newest to come under scrutiny and thus it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular is the fact that by right now there are not any long term prescription weightloss pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be authorized by the FDA.
Seizures are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug can also raise blood pressure level and heart rate, and shouldn't be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.
The FDA also warned that Contrave can raise hypertension and heart rate and must 't be used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients on the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.
The most common unwanted effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.