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Evidence is increasing that addiction without exception is related to difficulty with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in establishing food and sex, along with nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both whenever they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to shed weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you should err on the side of caution and let the FDA do its job and demand some research be done so the public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on the medications.
Researchers found that participants investing in this drug to get a year, dropped a few pounds within one month and have kept the weight off through the entire 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more effective and safer.
Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that by right now there aren't long term prescription diet pills that have been authorized by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA.
Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise blood pressure and heartbeat, and mustn't be used in those with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.
The FDA also warned that Contrave can raise blood pressure level and heart rate and must not be used in patients with uncontrolled high blood pressure levels, in addition to by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients towards the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.
Other people who must avoid using Contrave are patients struggling with bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave mustn't be prescribed for women who are pregnant or wanting to become pregnant.